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Meeting: 4th DNA Repair/Replication Structures and Cancer Conference
The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate DNA repair in the context of oncogene-induced replication stress and elevated transcription. Intertwined roles of repair with replication and transcription are emerging for dynamic complexes acting in genome stability and its loss in cancer. Moreover, the synthetic lethality and essentiality resulting from replication-repair stresses suggest strategies to define and predict pathway selection and damage outcomes as a foundation for advanced therapeutics that target Achilles heels for cancer.
The 4th DNA Repair/Replication Structures & Cancer conference in February 2020 will focus on structural and mechanistic insights into dynamic protein, chromatin, DNA and RNA complexes acting in DNA repair and its interface with DNA replication and transcription events relevant to cancer. This fundamental information will be pivotal for the accurate interpretation of cancer clinical data, design of clinical trials, prognosis, etiology and improving the currently 1/20 low success rate for oncology drug clinical trials. Informative talks and poster sessions along with vibrant discussions will foster productive interactions and collaborations.
All presenters are asked to focus on unpublished work, cutting-edge approaches and novel mechanistic insights that aid prediction of biological outcomes and plans to best apply basic research advances for cancer research and treatment. To include late-breaking advances and innovating new investigators, one or more talks for every session will be selected from submitted abstracts. Meeting attendance is limited. Applicants strongly encouraged to submit applications and abstracts early.